The endometrium undergoes a series of well-recognised cycles of proliferation, differentiation and tissue breakdown on a monthly basis, in response to exposure to the circulating sex steroids oestrogen and progesterone. Understanding the physiology behind these changes allows healthcare professionals to better counsel their patients on the immediate and longer-term bleeding patterns associated with various contraceptive methods.
Treatment for erectile dysfunction (ED) with phosphodiesterase-5 (PDE5) inhibitors is associated with a markedly reduced risk of death, and hospitalisation for heart failure. A team from the Karolinksa Institute in Stockholm conducted a nationwide cohort study which included over 43,000 men with a first MI in Sweden.
New research from a large national database shows an increased risk of adverse outcomes in babies born to mothers with gestational diabetes when compared with non-diabetic mothers. The database of all 797,346 deliveries in France in 2012 included 57,629 (7.24%) mothers with gestational diabetes. There was an increased risk of a number of complications for mothers with gestational diabetes compared with non-diabetic mothers.
The direct factor Xa inhibitor rivaroxaban has been showing promise in trials in venous thromboembolism (VTE) and peripheral arterial disease (PAD). We provide details from the EINSTEIN CHOICE and COMPASS trials.
This article provides an in-depth look at the role of carbohydrates in obesity, impaired glucose regulation and type 2 diabetes. Foods containing carbohydrates are an important part of a healthy diet for both the general population and those with, or at risk of, type 2 diabetes and cardiovascular disease. However foods and drinks high in ‘free sugars’ should be restricted.
Type 2 diabetes can be reversed with intensive medical treatment using medications and lifestyle therapies, according to a new study. Up to 40% of study participants were able to stay in remission three months after stopping diabetes medications.
Detailed results from the FOURIER cardiovascular outcomes trial on evolocumab were presented at a late-breaking oral presentation at the American College of Cardiology meeting in Washington DC recently. This is the first major outcomes study to be published for a PCSK9 inhibitor – a new class of cholesterol-lowering medicines.
Never a week goes by without carbohydrates hitting the headlines, with heated debates raging over low carb diets for weight loss to sugar as “the new tobacco”. Sorting fact from fiction is hard for health professionals and patients alike. In this article we go behind the headlines to explore the truth about carbohydrates in a healthy diet.
The British Heart Foundation is pressing for a renewed focus on improving the diagnosis and management of familial hypercholesterolaemia, and adoption of a nationwide cascade screening programme for first-degree relatives. The article includes best practice tips for busy primary healthcare professionals.